Absorption of chemicals by the skin

The fact sheet deals with exposure to chemical agents through the skin. Chemical substances, even if they are not corrosive and irritating, skincell pro reviews can be absorbed in large quantities through extensive contact with intact skin: their systematic toxic effects can be prevented not only by environmental control. Also, an injured skin requires additional precautions to be taken.

This fact sheet contains:

1. Evaluation methods of eventual dermal absorption of chemical substances:

   1. in vitro (cellular de Franz)

   2. in vivo (experimentation with “skinned” animals, experimentation with volunteers by applying adhesive tapes, “volatilization method”, application and measurement of excretion); 

1. Main absorption methods (based on histological characteristics of the skin)

2. Factors influencing skin absorption (chemical and physical characteristics of substances, skin characteristics, nature and duration of exposure, area of ​​exposed skin, moisture, physical activity)

3. Periodicity of phenomena caused by absorption by the skin

4. Evaluation methods of absorption by the skin:

   1. Directly (wash, clean the skin, eliminate tears)

   2. Indirectly (clean surfaces)

1. Normative references